哮喘是儿童最常见的慢性疾病,是儿童住院和旷课的主要原因。哮喘表现出不同的表型取决于年龄、性别、遗传背景、环境暴露和表观遗传因素。叉头盒O3 (Forkhead box O3, FOXO3)是参与多种炎症和呼吸系统疾病发病的转录因子。该研究旨在调查FOXO3基因SNP rs13217795与埃及人群儿童哮喘发病之间的关系。采用PCR-RFLP法对90例哮喘患者和160例健康对照者FOXO3 SNP (rs13217795)进行基因分型。哮喘组纯合子(CC)和杂合子(CT)基因型比例低于对照组,但无统计学意义;P > 0.05。哮喘组TT基因型突变率较高;30例(33.3%);28(17.5%),隐性模型疾病外显率差异显著,比值比OR (95% CI)为2.4(1 - 5.49),P=0.039。 This association was more pronounced in male gender; OR and 95% CI of 5.3 (1.4- 19.3) and P=0.01. In conclusions, Egyptian children carrying the mutant (TT) genotype were at higher risk to develop asthma with a higher risk in male gender.
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