疲劳是多发性硬化症(MS)最常见和致残的症状之一。它可以被定义为一种身体和精神能量的主观缺乏。本研究的目的是评估MS患者疲劳的频率和严重程度及其与整体体力活动和疾病相关残疾的关系。该研究包括了100例临床复发缓解型ms患者，严重抑郁症患者被排除。使用扩展残疾状态量表(EDSS)对神经功能障碍进行评分。采用改良疲劳影响量表(MFIS)和疲劳严重程度量表(FSS)进行疲劳评估，FSS得分大于36表示患者存在疲劳。采用国际体力活动问卷(IPAQ)评估体力活动，并使用标准代谢当量(MET)将体力活动分为低、中、高三个水平。FSS和MFIS评分(均数±标准差)分别为31.3±15.2和30.1±17.0。平均EDSS评分为2.5±1.5。42%。 Patients were classified as fatigued based on FSS. Fatigued patients had higher mean EDSS scores than non-fatigued (3.0 ± 1.6 vs. 2.2 ± 1.4, respectively, = 0.002). Low, moderate, and high levels of physical activity were reported in 35%, 20%, and 45% of patients, respectively. Higher scores of fatigue in FSS and MFIS were inversely correlated with the intensity of physical activity (r = -0.38, < 0.001 and r = -0.33, < 0.001, respectively). In patients with MS, fatigue is a common symptom. Patients with lower physical activity and greater MS-related disability have a higher severity of fatigue, which negatively affects cognitive, psychosocial, and physical functioning.