良性前列腺增生(BPH)是老年人中最普遍的条件之一。使用5α-还原酶抑制剂(5- aris)处理BPH与勃起功能障碍(ED)连接。许多药用植物和次生代谢物用于ED管理。洋葱(Allium cepa L.)是一种经济实惠的植物,具有重要的植物化学和生物学功能。该研究旨在鉴定洋葱汁对荷兰甾醇(5- ari)的有益作用 - 诱导的ed。将大鼠分为两组(每组n = 5):对照和荷兰甾克化物处理的大鼠(0.5mg / kg /天)。荷兰特德在饮用水中施用12周。实验在第12周结束时进行。在颅内治疗洋葱之前和之后测量体内勃起反应。在语料库孔(CC)中检查了对洋葱汁的松弛反应。 Acetylcholine (ACh)-, electrical field stimulation (EFS)-, sodium nitroprusside (SNP)-induced relaxation responses in CC tissues were evaluated in the absence and presence of onion juice. Total intracavernosal pressure (ICP) and ICP/ mean arterial pressure were significantly reduced in dutasteride-treated rats (1881.14 ± 249.72 mmHg, P < 0.001;0.26 ± 0.03, P < 0.01) as compared to control rats (4542.60 ± 429.19 mmHg, 0.51 ± 0.05), which was normalized after the intracavernous administration of onion (3288.60 ± 185.45 mmHg, 0.58 ± 0.04). Onion markedly induced relaxant responses in control (72.5 ± 4.7) and dutasteride-treated (66.5 ± 2.7) groups after precontraction with phenylephrine. Relaxation responses to onion were partially inhibited after precontraction with KCl (32.5 ± 3.1, P < 0.001). The relaxant responses to ACh (14.9 ± 4.2, P < 0.01) were diminished in dutasteride-treated CC) compared to control CC (59.8 ± 3.4), which was enhanced after the incubation with onion (36.6 ± 4.8). There were no differences in relaxation response to SNP among all groups. However, relaxation response to SNP was reduced in dutasteride-treated CC at 1 μM (P < 0.05) and 10 μM dosages (P < 0.001), which was partially increased after the incubation with onion at 10 μM dosage (P < 0.01). The presence of onion did not change the reduction in EFS-caused relaxation in the dutasteride-treated group. The current data suggest that red onion juice has a restorative effect on erectile function and endothelium-dependent relaxation response following the treatment of dutasteride.
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