氧化应激和炎症被认为是糖尿病视网膜病变的进展和发育的主要原因。目前,核因子红细胞-2相关因子2(NRF2),硫氧嗪相互作用蛋白(TXNIP)和NLRP3炎症途径在氧化应激和炎症相关疾病的研究中越来越关注。另一方面,由于其各种药理学性质,Tilianin(TN)受到了很多关注。基于这些研究的结果,进行该研究对糖尿病大鼠视网膜进行TN的治疗效率。任意分配大鼠三组:对照组,糖尿病组和糖尿病加入TN(20mg / kg体重42天,口服)组。糖尿病大鼠的补充,它们的食物摄入量,血糖状态,糖基化血红蛋白(HBA1C)水平大幅减少,并且血清胰岛素状态下显着的增强。糖尿病大鼠治疗NRF2及其靶基因的MRNA表达增加,HO-1,显着降低了丙二醛地位。超氧化物歧化酶(SOD),过氧化氢酶(猫)和谷胱甘肽过氧化物酶(GPX)的活性相对于糖尿病大鼠增加。此外,给予糖尿病大鼠的TN导致TXNIP,NOD样受体蛋白3(NLRP3),含有卡(ASC),Caspase-1和IL-1β蛋白的凋亡相关的蛋白质,凋亡相关的斑点的蛋白质的表达减少,并降低TXNIP,NLRP3,ASC和Caspase-1蛋白的分布在视网膜中。 In addition, TN treatment ameliorated morphological and morphometric changes in the retinas of diabetic rats. Together, all of these findings provide clear evidence that TN treatment of diabetic rats attenuated diabetic retinal changes through its hypoglycemic, antioxidant, and anti-inflammatory properties. The antioxidant and anti-inflammatory effects in diabetic retinas occur at least in part through the modulation of Nrf2/TXNIP/NLRP3 inflammasome pathways, which may have remedial benefits in the healing of diabetic retinopathy.

参考文献

PubMed.